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PDD patients had decreased CSF IGFBP3 level compared to PD patients. ELISA results of IGFBP3 detection showed that IGFBP3 concentration was lower in the CSF of PDD patients than PD patients ( n = 28 in PD group and n = 9 in PDD group). Columns with error bars present the mean ± SEM. Two-tailed unpaired t -tests. * p < 0.05.

Journal: Frontiers in Neuroscience

Article Title: Revealing cerebrospinal fluid biomarkers in Parkinson's disease dementia based on iTRAQ proteomics research

doi: 10.3389/fnins.2025.1682274

Figure Lengend Snippet: PDD patients had decreased CSF IGFBP3 level compared to PD patients. ELISA results of IGFBP3 detection showed that IGFBP3 concentration was lower in the CSF of PDD patients than PD patients ( n = 28 in PD group and n = 9 in PDD group). Columns with error bars present the mean ± SEM. Two-tailed unpaired t -tests. * p < 0.05.

Article Snippet: Concentrations of IGFBP3, NXPH1, LRRN1, and HPRT1 in CSF were measured using human ELISA kits (IGFBP3: CSB-E04590h, CUSABIO, China; NXPH1: ELK3869, ELK Biotechnology, China; LRRN1: MBS2602720, MyBioSource, USA; HPRT1: ELK3546, ELK Biotechnology, China).

Techniques: Enzyme-linked Immunosorbent Assay, Concentration Assay, Two Tailed Test